There are 25 flights from Tijuana airport, Mexico to USA, operated by 3 airlines. You can fly low cost from Tijuana airport to 19 cities in USA.
Chicago Midway, IL
Chicago O'Hare, IL
Dallas/Fort Worth, TX
Denver, CO
Denver, CO
Fresno Yosemite
Fresno Yosemite
George Bush Intercontinental
Hartsfield-Jackson Atlanta
Las Vegas, NV
Las Vegas, NV
Los Angeles, CA
Miami, FL
New Orleans, LA
New York JFK
Ontario, CA
Orlando, FL
Orlando, FL
Phoenix, AZ
Phoenix, AZ
Sacramento, CA
Sacramento, CA
San Antonio, TX
San Francisco, CA
Washington Dulles, DC
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Check the cancellation policy: Usually, if you choose the lowest fare you will not be allowed to freely modify you flight details later on (change dates or passenger names, etc). If you think that you might need to do this, you should consider buying a more flexible (but also more expensive) ticket.